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Duration of T Cell Stimulation as a Critical Determinant of Cell Fate and Plasticity
T cell receptor (TCR) signal strength determines the differentiation outcome of naïve CD4(+) T cells: low signal strength favors Foxp3(pos) regulatory T cells (Treg) whereas high TCR signals are required to induce IL-2-producing helper T cells (Th). To better understand the signaling requirements fo...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4074924/ https://ncbi.nlm.nih.gov/pubmed/24194584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004217 |
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