The Anorectic Actions of the TGFβ Cytokine MIC-1/GDF15 Require an Intact Brainstem Area Postrema and Nucleus of the Solitary Tract

Macrophage inhibitory cytokine-1 (MIC-1/GDF15) modulates food intake and body weight under physiological and pathological conditions by acting on the hypothalamus and brainstem. When overexpressed in disease, such as in advanced cancer, elevated serum MIC-1/GDF15 levels lead to an anorexia/cachexia...

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Autors principals: Tsai, Vicky Wang-Wei, Manandhar, Rakesh, Jørgensen, Sebastian Beck, Lee-Ng, Ka Ki Michelle, Zhang, Hong Ping, Marquis, Christopher Peter, Jiang, Lele, Husaini, Yasmin, Lin, Shu, Sainsbury, Amanda, Sawchenko, Paul E., Brown, David A., Breit, Samuel N.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074070/
https://ncbi.nlm.nih.gov/pubmed/24971956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100370
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