Hydrogen sulfide dilates rat mesenteric arteries by activating endothelial large-conductance Ca(2+)-activated K(+) channels and smooth muscle Ca(2+) sparks

We have previously shown that hydrogen sulfide (H(2)S) reduces myogenic tone and causes relaxation of phenylephrine (PE)-constricted mesenteric arteries. This effect of H(2)S to cause vasodilation and vascular smooth muscle cell (VSMC) hyperpolarization was mediated by large-conductance Ca(2+)-activ...

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Hlavní autoři: Jackson-Weaver, Olan, Osmond, Jessica M., Riddle, Melissa A., Naik, Jay S., Bosc, Laura V. Gonzalez, Walker, Benjimen R., Kanagy, Nancy L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2013
Témata:
Vascular Biology and Microcirculation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073893/
https://ncbi.nlm.nih.gov/pubmed/23525712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00506.2012
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