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Local effect of IL-4 delivery on polyethylene particle induced osteolysis in the murine calvarium

Wear particles generated with use of total joint replacements incite a chronic macrophage-mediated inflammatory reaction, which leads to implant failure. Macrophage activation may be polarized into two states, with an M1 proinflammatory state dominating an alternatively activated M2 anti-inflammator...

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Main Authors: Rao, Allison J., Nich, Christophe, Dhulipala, Lakshmi S., Gibon, Emmanuel, Valladares, Roberto, Zwingenberger, Stefan, Smith, R. Lane, Goodman, Stuart B.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073780/
https://ncbi.nlm.nih.gov/pubmed/23225668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm.a.34486
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