Reversal of Acquired Drug Resistance in FLT3-mutated Acute Myeloid Leukemia Cells via Distinct Drug Combination Strategies

PURPOSE: FMS-like tyrosine kinase-3 (FLT3) internal tandem duplication (FLT3-ITD) mutations are common in patients with acute myeloid leukemia (AML). These patients regularly develop resistance to FLT3 inhibitors suggesting that targeted combination drug strategies are needed to enhance AML therapy...

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Hauptverfasser: Zhang, Weiguo, Gao, Chen, Konopleva, Marina, Chen, Ye, Jacamo, Rodrigo O., Borthakur, Gautam, Cortes, Jorge E., Ravandi, Farhad, Ramachandran, Abhijit, Andreeff, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073635/
https://ncbi.nlm.nih.gov/pubmed/24619500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2052
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