Ataxia telangiectasia derived iPS cells show preserved x-ray sensitivity and decreased chromosomal instability

Ataxia telangiectasia is a neurodegenerative inherited disease with chromosomal instability and hypersensitivity to ionizing radiation. iPS cells lacking ATM (AT-iPS cells) exhibited hypersensitivity to X-ray irradiation, one of the characteristics of the disease. While parental ataxia telangiectasi...

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Main Authors: Fukawatase, Yoshihiro, Toyoda, Masashi, Okamura, Kohji, Nakamura, Ken-ichi, Nakabayashi, Kazuhiko, Takada, Shuji, Yamazaki-Inoue, Mayu, Masuda, Akira, Nasu, Michiyo, Hata, Kenichiro, Hanaoka, Kazunori, Higuchi, Akon, Takubo, Kaiyo, Umezawa, Akihiro
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073166/
https://ncbi.nlm.nih.gov/pubmed/24970375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05421
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