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Mechanical coupling maintains the fidelity of NMDA receptor-mediated currents
The fidelity of NMDA receptors (NMDARs) to integrate pre- and post-synaptic activity requires a match between agonist binding and ion channel opening. To address how agonist binding is transduced into pore opening in NMDARs, we manipulated the coupling between the ligand binding domain (LBD) and the...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4072853/ https://ncbi.nlm.nih.gov/pubmed/24859202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3724 |
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