Cytoplasmic Viral RNA-Dependent RNA Polymerase Disrupts the Intracellular Splicing Machinery by Entering the Nucleus and Interfering with Prp8

The primary role of cytoplasmic viral RNA-dependent RNA polymerase (RdRp) is viral genome replication in the cellular cytoplasm. However, picornaviral RdRp denoted 3D polymerase (3D(pol)) also enters the host nucleus, where its function remains unclear. In this study, we describe a novel mechanism o...

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Main Authors: Liu, Yen-Chin, Kuo, Rei-Lin, Lin, Jing-Yi, Huang, Peng-Nien, Huang, Yi, Liu, Hsuan, Arnold, Jamine J., Chen, Shu-Jen, Wang, Robert Yung-Liang, Cameron, Craig E., Shih, Shin-Ru
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072778/
https://ncbi.nlm.nih.gov/pubmed/24968230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004199
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