Deletion of the Highly Conserved N-Glycan at Asn260 of HIV-1 gp120 Affects Folding and Lysosomal Degradation of gp120, and Results in Loss of Viral Infectivity

N-linked glycans covering the surface of the HIV-1 glycoprotein gp120 are of major importance for the correct folding of this glycoprotein. Of the, on average, 24 N-linked glycans present on gp120, the glycan at Asn260 was reported to be essential for the correct expression of gp120 and gp41 in the...

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Bibliographic Details
Main Authors: Mathys, Leen, François, Katrien O., Quandte, Matthias, Braakman, Ineke, Balzarini, Jan
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072736/
https://ncbi.nlm.nih.gov/pubmed/24967714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101181
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