The regulator of G protein signaling (RGS) domain of G protein–coupled receptor kinase 5 (GRK5) regulates plasma membrane localization and function

The G protein–coupled receptor (GPCR) kinases (GRKs) phosphorylate activated GPCRs at the plasma membrane (PM). Here GRK5/GRK4 chimeras and point mutations in GRK5 identify a short sequence within the regulator of G protein signaling (RGS) domain in GRK5 that is critical for GRK5 PM localization. Th...

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Main Authors: Xu, Hua, Jiang, Xiaoshan, Shen, Ke, Fischer, Christopher C., Wedegaertner, Philip B.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072583/
https://ncbi.nlm.nih.gov/pubmed/24807909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-09-0547
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