MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly

The regulation of Rho-family GTPases is crucial to direct the formation of cell–cell junctions and tissue barriers. Cingulin (CGN) and paracingulin (CGNL1) control RhoA activation in epithelial cells by interacting with RhoA guanidine exchange factors. CGNL1 depletion also inhibits Rac1 activation d...

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Bibliographic Details
Main Authors: Guillemot, Laurent, Guerrera, Diego, Spadaro, Domenica, Tapia, Rocio, Jond, Lionel, Citi, Sandra
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072573/
https://ncbi.nlm.nih.gov/pubmed/24807907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-11-0680
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