NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB

NOTCH-dependent signaling pathways are critical for normal bone remodeling; however, it is unclear if dysfunctional NOTCH activation contributes to inflammation-mediated bone loss, as observed in rheumatoid arthritis (RA) patients. We performed RNA sequencing and pathway analyses in mesenchymal stem...

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Autors principals: Zhang, Hengwei, Hilton, Matthew J., Anolik, Jennifer H., Welle, Stephen L., Zhao, Chen, Yao, Zhenqiang, Li, Xing, Wang, Zhiyu, Boyce, Brendan F., Xing, Lianping
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071381/
https://ncbi.nlm.nih.gov/pubmed/24892805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI68901
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