Four individually druggable MET hotspots mediate HGF-driven tumor progression

Activation of MET by HGF plays a key role in tumor progression. Using a recently developed llama platform that generates human-like immunoglobulins, we selected 68 different antibodies that compete with HGF for binding to MET. HGF-competing antibodies recognized 4 distinct hotspots localized in diff...

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Detalhes bibliográficos
Main Authors: Basilico, Cristina, Hultberg, Anna, Blanchetot, Christophe, de Jonge, Natalie, Festjens, Els, Hanssens, Valérie, Osepa, Sjudry-Ilona, De Boeck, Gitte, Mira, Alessia, Cazzanti, Manuela, Morello, Virginia, Dreier, Torsten, Saunders, Michael, de Haard, Hans, Michieli, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071368/
https://ncbi.nlm.nih.gov/pubmed/24865428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72316
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