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Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors
The role of paracrine Hepatocyte Growth Factor (HGF) in the resistance to angiogenesis inhibitors (AIs) is hidden in xenograft models because mouse HGF fails to fully activate human MET. To uncover it, we compared the efficacy of AIs in wild-type and human HGF knock-in SCID mice bearing orthotopic h...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5503526/ https://ncbi.nlm.nih.gov/pubmed/28445144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16942 |
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