Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors

The role of paracrine Hepatocyte Growth Factor (HGF) in the resistance to angiogenesis inhibitors (AIs) is hidden in xenograft models because mouse HGF fails to fully activate human MET. To uncover it, we compared the efficacy of AIs in wild-type and human HGF knock-in SCID mice bearing orthotopic h...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncotarget
Egile Nagusiak: Mira, Alessia, Morello, Virginia, Céspedes, Maria Virtudes, Perera, Timothy, Comoglio, Paolo M., Mangues, Ramon, Michieli, Paolo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2017
Gaiak:
Research Paper: Autophagy and Cell Death
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503526/
https://ncbi.nlm.nih.gov/pubmed/28445144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16942
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