Cellular, pharmacological, and biophysical evaluation of explanted lungs from a patient with sickle cell disease and severe pulmonary arterial hypertension

Abstract. Pulmonary hypertension is recognized as a leading cause of morbidity and mortality in patients with sickle cell disease (SCD). We now report benchtop phenotyping from the explanted lungs of the first successful lung transplant in SCD. Pulmonary artery smooth muscle cells (PASMCs) cultured...

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Detalhes bibliográficos
Main Authors: Rogers, Natasha M., Yao, Mingyi, Sembrat, John, George, M. Patricia, Knupp, Heather, Ross, Mark, Sharifi-Sanjani, Maryam, Milosevic, Jadranka, St. Croix, Claudette, Rajkumar, Revathi, Frid, Maria G., Hunter, Kendall S., Mazzaro, Luciano, Novelli, Enrico M., Stenmark, Kurt R., Gladwin, Mark T., Ahmad, Ferhaan, Champion, Hunter C., Isenberg, Jeffrey S.
Formato: Artigo
Idioma:Inglês
Publicado em: University of Chicago Press 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070844/
https://ncbi.nlm.nih.gov/pubmed/25006410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/674754
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