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Subcellular mechanisms in pulmonary arterial hypertension: combinatorial modalities that inhibit anterograde trafficking and cause bone morphogenetic protein receptor type 2 mislocalization
Abstract. The natural history of familial pulmonary arterial hypertension (PAH) typically involves mutations in and/or haploinsuffciency of BMPR2 (gene for bone morphogenetic protein receptor type 2) but with low penetrance (10%–15%), delayed onset (in the third or fourth decade), and a gender bias...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
University of Chicago Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4070808/ https://ncbi.nlm.nih.gov/pubmed/24618539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/674336 |
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