Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas

PURPOSE: Isocitrate dehydrogenase (IDH) gene mutations occur in low-grade and high-grade gliomas. We sought to identify the genetic basis of malignant phenotype heterogeneity in IDH-mutant gliomas. METHODS: We prospectively implanted tumor specimens from 20 consecutive IDH1-mutant glioma resections...

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Hlavní autoři: Wakimoto, Hiroaki, Tanaka, Shota, Curry, William T., Loebel, Franziska, Zhao, Dan, Tateishi, Kensuke, Chen, Juxiang, Klofas, Lindsay K., Lelic, Nina, Kim, James C., Dias-Santagata, Dora, Ellisen, Leif W., Borger, Darrell R., Fendt, Sarah-Maria, Heiden, Matthew G. Vander, Batchelor, Tracy T., Iafrate, A. John, Cahill, Daniel P., Chi, Andrew S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070445/
https://ncbi.nlm.nih.gov/pubmed/24714777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-3052
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