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Molecular Dynamics Simulations Elucidate the Mechanism of Proton Transport in the Glutamate Transporter EAAT3

The uptake of glutamate in nerve synapses is carried out by the excitatory amino acid transporters (EAATs), involving the cotransport of a proton and three Na(+) ions and the countertransport of a K(+) ion. In this study, we use an EAAT3 homology model to calculate the pK(a) of several titratable re...

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Hlavní autoři: Heinzelmann, Germano, Kuyucak, Serdar
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070078/
https://ncbi.nlm.nih.gov/pubmed/24940785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.05.010
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