Preparation and characterization of celecoxib solid dispersions; comparison of poloxamer-188 and PVP-K30 as carriers

OBJECTIVE(S): Solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. The aim of this study was to compare the effect of polyvinylpyrrolidone K30 (PVP) and poloxamer-188 (PLX) as carrier in solid dispersion formulations of celecoxib...

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Bibliographic Details
Main Authors: Homayouni, Alireza, Sadeghi, Fatemeh, Nokhodchi, Ali, Varshosaz, Jaleh, Garekani, Hadi Afrasiabi
Format: Artigo
Language:Inglês
Published: Mashhad University of Medical Sciences 2014
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4069839/
https://ncbi.nlm.nih.gov/pubmed/24967060
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