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RAGE Inhibition in Microglia Prevents Ischemia-Dependent Synaptic Dysfunction in an Amyloid-Enriched Environment

Ischemia is known to increase the deleterious effect of β-amyloid (Aβ), contributing to early cognitive impairment in Alzheimer's disease. Here, we investigated whether transient ischemia may function as a trigger for Aβ-dependent synaptic impairment in the entorhinal cortex (EC), acting throug...

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Bibliografiske detaljer
Main Authors: Origlia, Nicola, Criscuolo, Chiara, Arancio, Ottavio, Yan, Shirley ShiDu, Domenici, Luciano
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4069353/
https://ncbi.nlm.nih.gov/pubmed/24966375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0141-14.2014
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