Microglial Receptor for Advanced Glycation End Product-Dependent Signal Pathway Drives β-Amyloid-Induced Synaptic Depression and Long-Term Depression Impairment in Entorhinal Cortex

Overproduction of β-amyloid (Aβ) is a pathologic feature of Alzheimer's disease, leading to cognitive impairment. Here, we investigated the impact of cell-specific receptor for advanced glycation end products (RAGE) on Aβ-induced entorhinal cortex (EC) synaptic dysfunction. We found both a tran...

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Detalhes bibliográficos
Main Authors: Origlia, Nicola, Bonadonna, Camilla, Rosellini, Alfredo, Leznik, Elena, Arancio, Ottavio, Yan, Shirley ShiDu, Domenici, Luciano
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842472/
https://ncbi.nlm.nih.gov/pubmed/20739563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2127-10.2010
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