Impaired Emotional Learning and Involvement of the Corticotropin-Releasing Factor Signaling System in Patients with Irritable Bowel Syndrome

BACKGROUND & AIMS: Alterations in central corticotropin-releasing factor (CRF) signaling pathways have been implicated in the pathophysiology of anxiety disorders and irritable bowel syndrome (IBS). We aimed to characterize the effects of the CRF receptor 1 (CRF-R1) antagonist, GW876008, on brai...

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Detalhes bibliográficos
Main Authors: Labus, Jennifer S., Hubbard, Catherine S., Bueller, Joshua, Ebrat, Bahar, Tillisch, Kirsten, Chen, Michelle, Stains, Jean, Dukes, George E., Kelleher, Dennis L., Naliboff, Bruce D., Fanselow, Michael, Mayer, Emeran A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4069031/
https://ncbi.nlm.nih.gov/pubmed/23954313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2013.08.016
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