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Corticotropin-Releasing Factor Receptor 1 Antagonist Alters Regional Activation and Effective Connectivity in an Emotional–Arousal Circuit during Expectation of Abdominal Pain

Alterations in corticotropin-releasing factor (CRF) signaling pathways have been implicated in irritable bowel syndrome (IBS) pathophysiology. We aimed to (1) determine the effect of the selective CRF receptor 1 antagonist (CRF(1)) GW876008 relative to placebo, on regional activation and effective c...

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Detalhes bibliográficos
Main Authors: Hubbard, Catherine S., Labus, Jennifer S., Bueller, Joshua, Stains, Jean, Suyenobu, Brandall, Dukes, George E., Kelleher, Dennis L., Tillisch, Kirsten, Naliboff, Bruce D., Mayer, Emeran A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399687/
https://ncbi.nlm.nih.gov/pubmed/21880911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1860-11.2011
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