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Activities of Ceftazidime and Avibactam against β-Lactamase-Producing Enterobacteriaceae in a Hollow-Fiber Pharmacodynamic Model

Avibactam is a novel non-β-lactam β-lactamase inhibitor that is currently undergoing phase 3 clinical trials in combination with ceftazidime. Ceftazidime is hydrolyzed by a broad range of β-lactamases, but avibactam is able to inhibit the majority of these enzymes. The studies described here attempt...

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Bibliografische gegevens
Hoofdauteurs: Coleman, Ken, Levasseur, Premavathy, Girard, Anne-Marie, Borgonovi, Monica, Miossec, Christine, Merdjan, Henri, Drusano, George, Shlaes, David, Nichols, Wright W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2014
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068505/
https://ncbi.nlm.nih.gov/pubmed/24687507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00080-14
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