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Simplified Equations Using Two Concentrations To Calculate Area under the Curve for Antimicrobials with Concentration-Dependent Pharmacodynamics: Daptomycin as a Motivating Example

The effects of several antimicrobial agents are predicted by the ratio of the area under the concentration-time curve (AUC) to the MIC (AUC/MIC). Peak (C(p)) and trough (C(t)) concentrations are often measured clinically as surrogates of AUC because actual computation of AUC from 1 or 2 samples requ...

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Autori principali: Pai, Manjunath P., Russo, Alessandro, Novelli, Andrea, Venditti, Mario, Falcone, Marco
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068499/
https://ncbi.nlm.nih.gov/pubmed/24663017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02355-14
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