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Simplified Equations Using Two Concentrations To Calculate Area under the Curve for Antimicrobials with Concentration-Dependent Pharmacodynamics: Daptomycin as a Motivating Example
The effects of several antimicrobial agents are predicted by the ratio of the area under the concentration-time curve (AUC) to the MIC (AUC/MIC). Peak (C(p)) and trough (C(t)) concentrations are often measured clinically as surrogates of AUC because actual computation of AUC from 1 or 2 samples requ...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4068499/ https://ncbi.nlm.nih.gov/pubmed/24663017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02355-14 |
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