Identification of AP80978, a Novel Small-Molecule Inhibitor of Hepatitis C Virus Replication That Targets NS4B

A small-molecule inhibitor of hepatitis C virus (HCV) designated AP89652 was identified by screening a compound library with an HCV genotype 1b subgenomic replicon assay. AP89652 contains two chiral centers, and testing of two syn enantiomers revealed that activity in the replicon assay resided with...

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Detalhes bibliográficos
Main Authors: Dufner-Beattie, Jodi, O'Guin, Andrew, O'Guin, Stephanie, Briley, Aaron, Wang, Bin, Balsarotti, Jennifer, Roth, Robert, Starkey, Gale, Slomczynska, Urszula, Noueiry, Amine, Olivo, Paul D., Rice, Charles M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068439/
https://ncbi.nlm.nih.gov/pubmed/24709254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00113-14
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