Altered Pharmacokinetics of Piperacillin in Febrile Neutropenic Patients with Hematological Malignancy

This study assessed the pharmacokinetics and dosing adequacy of piperacillin in febrile neutropenic patients after the first dose. Pharmacokinetic analysis was performed using noncompartmental methods. We observed an elevated volume of distribution (29.7 ± 8.0 liters [mean ± standard deviation]) and...

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Главные авторы: Sime, Fekade Bruck, Roberts, Michael S., Warner, Morgyn S., Hahn, Uwe, Robertson, Thomas A., Yeend, Sue, Phay, Andy, Lehman, Sheila, Lipman, Jeffrey, Peake, Sandra L., Roberts, Jason A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2014
Предметы:
Pharmacology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068433/
https://ncbi.nlm.nih.gov/pubmed/24687508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02340-14
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