Does Beta-lactam Pharmacokinetic Variability in Critically Ill Patients Justify Therapeutic Drug Monitoring? A Systematic Review

The pharmacokinetics of beta-lactam antibiotics in intensive care patients may be profoundly altered due to the dynamic, unpredictable pathophysiological changes that occur in critical illness. For many drugs, significant increases in the volume of distribution and/or variability in drug clearance a...

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Main Authors: Sime, Fekade Bruck, Roberts, Michael S, Peake, Sandra L, Lipman, Jeffrey, Roberts, Jason A
Format: Artigo
Jezik:Inglês
Izdano: Springer 2012
Teme:
Review
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460787/
https://ncbi.nlm.nih.gov/pubmed/22839761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2110-5820-2-35
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