Does Beta-lactam Pharmacokinetic Variability in Critically Ill Patients Justify Therapeutic Drug Monitoring? A Systematic Review

The pharmacokinetics of beta-lactam antibiotics in intensive care patients may be profoundly altered due to the dynamic, unpredictable pathophysiological changes that occur in critical illness. For many drugs, significant increases in the volume of distribution and/or variability in drug clearance a...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Sime, Fekade Bruck, Roberts, Michael S, Peake, Sandra L, Lipman, Jeffrey, Roberts, Jason A
Format: Artigo
Langue:Inglês
Publié: Springer 2012
Sujets:
Review
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460787/
https://ncbi.nlm.nih.gov/pubmed/22839761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2110-5820-2-35
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