Evaluation of Ceftaroline, Vancomycin, Daptomycin, or Ceftaroline plus Daptomycin against Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus in an In Vitro Pharmacokinetic/Pharmacodynamic Model of Simulated Endocardial Vegetations

Infective endocarditis (IE) caused by methicillin-resistant Staphylococcus aureus (MRSA) with reduced susceptibility to vancomycin and daptomycin has few adequate therapeutic options. Ceftaroline (CPT) is bactericidal against daptomycin (DAP)-nonsusceptible (DNS) and vancomycin-intermediate MRSA, bu...

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Bibliographic Details
Main Authors: Werth, Brian J., Barber, Katie E., Ireland, Cortney E., Rybak, Michael J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068431/
https://ncbi.nlm.nih.gov/pubmed/24663016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00088-14
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