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Hyperglycemia Induces Embryopathy, Even in the Absence of Systemic Maternal Diabetes: An In Vivo Test of the Fuel Mediated Teratogenesis Hypothesis

Embryonic exposure to excess circulating fuels is proposed to underlie diabetic embryopathy. To isolate the effects of hyperglycemia from the many systemic anomalies of diabetes, we infused 4 mg/min glucose into the left uterine artery of non-diabetic pregnant rats on gestation days (GD) 7–9. Right-...

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Detalhes bibliográficos
Main Authors: Baack, Michelle L., Wang, Chunlin, Hu, Shanming, Segar, Jeffrey L., Norris, Andrew W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067982/
https://ncbi.nlm.nih.gov/pubmed/24721120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.reprotox.2014.03.013
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