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The case for DUF1220 domain dosage as a primary contributor to anthropoid brain expansion

Here we present the hypothesis that increasing copy number (dosage) of sequences encoding DUF1220 protein domains is a major contributor to the evolutionary increase in brain size, neuron number, and cognitive capacity that is associated with the primate order. We further propose that this relations...

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Autori principali: Keeney, Jonathon G., Dumas, Laura, Sikela, James M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067907/
https://ncbi.nlm.nih.gov/pubmed/25009482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnhum.2014.00427
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