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The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation, and cell migration
Rac1-GTPases serve as intermediary cellular switches which conduct transient and constitutive signals from upstream cues, including those from Ras oncoproteins. While the sirtuin1 (SIRT1) deacetylase is overexpressed in several human cancers and has recently been linked to cancer cell motility as a...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4067478/ https://ncbi.nlm.nih.gov/pubmed/24362520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.549 |
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