Nodal·Gdf1 Heterodimers with Bound Prodomains Enable Serum-independent Nodal Signaling and Endoderm Differentiation

The TGFβ family member Nodal is central to control pluripotent stem cell fate, but its use as a stem cell differentiation factor is limited by low specific activity. During development, Nodal depends on growth and differentiation factor (Gdf)-1 and on the shared co-receptor Cryptic to specify viscer...

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Bibliographic Details
Main Authors: Fuerer, Christophe, Nostro, M. Cristina, Constam, Daniel B.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067217/
https://ncbi.nlm.nih.gov/pubmed/24798330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.550301
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