N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of Novel Orthopoxvirus Egress Inhibitors

A series of novel, potent orthopoxvirus egress inhibitors was identified during high-throughput screening of the ViroPharma small molecule collection. Using SAR information inferred from early hits, several compounds were synthesized, and compound 14 was identified as a potent, orally bioavailable f...

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Bibliographic Details
Main Authors: Bailey, Thomas R., Rippin, Susan R., Opsitnick, Elizabeth, Burns, Christopher J., Pevear, Daniel C., Collett, Marc S., Rhodes, Gerry, Tohan, Sanjeev, Huggins, John W., Baker, Robert O., Kern, Earl R., Keith, Kathy A., Dai, Dongcheng, Yang, Guang, Hruby, Dennis, Jordan, Robert
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067006/
https://ncbi.nlm.nih.gov/pubmed/17335190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm061484y
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