N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of Novel Orthopoxvirus Egress Inhibitors

A series of novel, potent orthopoxvirus egress inhibitors was identified during high-throughput screening of the ViroPharma small molecule collection. Using SAR information inferred from early hits, several compounds were synthesized, and compound 14 was identified as a potent, orally bioavailable f...

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Autors principals: Bailey, Thomas R., Rippin, Susan R., Opsitnick, Elizabeth, Burns, Christopher J., Pevear, Daniel C., Collett, Marc S., Rhodes, Gerry, Tohan, Sanjeev, Huggins, John W., Baker, Robert O., Kern, Earl R., Keith, Kathy A., Dai, Dongcheng, Yang, Guang, Hruby, Dennis, Jordan, Robert
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067006/
https://ncbi.nlm.nih.gov/pubmed/17335190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm061484y
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