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N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of Novel Orthopoxvirus Egress Inhibitors
A series of novel, potent orthopoxvirus egress inhibitors was identified during high-throughput screening of the ViroPharma small molecule collection. Using SAR information inferred from early hits, several compounds were synthesized, and compound 14 was identified as a potent, orally bioavailable f...
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| Autors principals: | , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4067006/ https://ncbi.nlm.nih.gov/pubmed/17335190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm061484y |
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