Complex of the herpes simplex virus type 1 origin binding protein UL9 with DNA as a platform for the design of a new type of antiviral drugs

The herpes simplex virus type 1 origin-binding protein, OBP, is a DNA helicase encoded by the UL9 gene. The protein binds in a sequence-specific manner to the viral origins of replication, two OriS sites and one OriL site. In order to search for efficient inhibitors of the OBP activity, we have obta...

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Detalhes bibliográficos
Main Authors: Bazhulina, N.P., Surovaya, A.N., Gursky, Y.G., Andronova, V.L., Moiseeva, E.D., Nikitin, A.M., Golovkin, M.V., Galegov, G.A., Grokhovsky, S.L., Gursky, G.V.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066892/
https://ncbi.nlm.nih.gov/pubmed/23879454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/07391102.2013.820110
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