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Complex of the herpes simplex virus type 1 origin binding protein UL9 with DNA as a platform for the design of a new type of antiviral drugs
The herpes simplex virus type 1 origin-binding protein, OBP, is a DNA helicase encoded by the UL9 gene. The protein binds in a sequence-specific manner to the viral origins of replication, two OriS sites and one OriL site. In order to search for efficient inhibitors of the OBP activity, we have obta...
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Main Authors: | , , , , , , , , , |
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格式: | Artigo |
語言: | Inglês |
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Taylor & Francis
2013
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在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4066892/ https://ncbi.nlm.nih.gov/pubmed/23879454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/07391102.2013.820110 |
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