Potential Mitochondrial Isocitrate Dehydrogenase R140Q Mutant Inhibitor from Traditional Chinese Medicine against Cancers

A recent research of cancer has indicated that the mutant of isocitrate dehydrogenase 1 and 2 (IDH1 and 2) genes will induce various cancers, including chondrosarcoma, cholangiocarcinomas, and acute myelogenous leukemia due to the effect of point mutations in the active-site arginine residues of iso...

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Bibliographic Details
Main Authors: Lee, Wen-Yuan, Chen, Kuan-Chung, Chen, Hsin-Yi, Chen, Calvin Yu-Chian
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066711/
https://ncbi.nlm.nih.gov/pubmed/24995286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/364625
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