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In Silico Investigation of Potential PARP-1 Inhibitors from Traditional Chinese Medicine
Poly(ADP-ribose) polymerases (PARPs) are nuclear enzymes which catalyze the poly-ADP-ribosylation involved in gene transcription, DNA damage repair, and cell-death signaling. As PARP-1 protein contains a DNA-binding domain, which can bind to DNA strand breaks and repair the damaged DNA over a low ba...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Hindawi Publishing Corporation
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4021748/ https://ncbi.nlm.nih.gov/pubmed/24876881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/917605 |
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