In Silico Investigation of Potential PARP-1 Inhibitors from Traditional Chinese Medicine

Poly(ADP-ribose) polymerases (PARPs) are nuclear enzymes which catalyze the poly-ADP-ribosylation involved in gene transcription, DNA damage repair, and cell-death signaling. As PARP-1 protein contains a DNA-binding domain, which can bind to DNA strand breaks and repair the damaged DNA over a low ba...

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Autores principales: Chen, Kuan-Chung, Sun, Mao-Feng, Chen, Calvin Yu-Chian
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021748/
https://ncbi.nlm.nih.gov/pubmed/24876881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/917605
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