Expression and Y435-phosphorylation of Abelson interactor 1 (Abi1) promotes tumour cell adhesion, extracellular matrix degradation and invasion by colorectal carcinoma cells

BACKGROUND: The Abelson tyrosine kinase (c-Abl) inhibitor STI571 (Glivec®) has been shown to effectively inhibit colorectal cancer cell migration and invasion. The c-Abl substrate abelson interactor 1 (Abi1) is a key regulator of actin reorganization and upregulated in colorectal carcinoma. The spec...

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Detalhes bibliográficos
Main Authors: Steinestel, Konrad, Brüderlein, Silke, Lennerz, Jochen K, Steinestel, Julie, Kraft, Klaus, Pröpper, Christian, Meineke, Viktor, Möller, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066275/
https://ncbi.nlm.nih.gov/pubmed/24913355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-145
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