Association of Levels of Fasting Glucose and Insulin with Rare Variants at the Chromosome 11p11.2-MADD Locus: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study

BACKGROUND: Common variation at the 11p11.2 locus, encompassing MADD, ACP2, NR1H3, MYBPC3 and SPI1, has been associated in genome-wide association studies with fasting glucose (FG) and insulin (FI). In the Cohorts for Heart and Aging Research in Genomic Epidemiology Targeted Sequencing Study, we seq...

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Main Authors: Cornes, Belinda K., Brody, Jennifer A., Nikpoor, Naghmeh, Morrison, Alanna C., Chu, Huan, Ahn, Byung Soo, Wang, Shuai, Dauriz, Marco, Barzilay, Joshua I., Dupuis, Josée, Florez, Jose C., Coresh, Josef, Gibbs, Richard A., Kao, W.H. Linda, Liu, Ching-Ti, McKnight, Barbara, Muzny, Donna, Pankow, James S., Reid, Jeffrey G., White, Charles C., Johnson, Andrew D., Wong, Tien Y., Psaty, Bruce M., Boerwinkle, Eric, Rotter, Jerome I, Siscovick, David S., Sladek, Robert, Meigs, James B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066205/
https://ncbi.nlm.nih.gov/pubmed/24951664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.113.000169
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