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Hemodynamic Disturbed Flow Induces Differential DNA Methylation of Endothelial Kruppel-Like Factor 4 (KLF4) Promoter in vitro and in vivo
RATIONALE: Hemodynamic disturbed flow is associated with susceptibility to atherosclerosis. Endothelial KLF4 is an important anti-inflammatory atheroprotective transcription factor that is suppressed in regions of disturbed flow. OBJECTIVE: The plasticity of epigenomic KLF4 transcriptional regulatio...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4065854/ https://ncbi.nlm.nih.gov/pubmed/24755985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.303883 |
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