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Hemodynamic Disturbed Flow Induces Differential DNA Methylation of Endothelial Kruppel-Like Factor 4 (KLF4) Promoter in vitro and in vivo

RATIONALE: Hemodynamic disturbed flow is associated with susceptibility to atherosclerosis. Endothelial KLF4 is an important anti-inflammatory atheroprotective transcription factor that is suppressed in regions of disturbed flow. OBJECTIVE: The plasticity of epigenomic KLF4 transcriptional regulatio...

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Bibliografski detalji
Glavni autori: Jiang, Yi-Zhou, Jiménez, Juan M., Ou, Kristy, McCormick, Margaret E., Zhang, Ling-Di, Davies, Peter F
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065854/
https://ncbi.nlm.nih.gov/pubmed/24755985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.303883
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