Solubility and Bioavailability Enhancement of Poorly Aqueous Soluble Atorvastatin: In Vitro, Ex Vivo, and In Vivo Studies

The objective of this investigation was to improve the solubility of the poorly water soluble drug atorvastatin (ATR), using solid dispersion (SD) techniques, with Neem Gum (NG) as a hydrophilic carrier. The effects of the polymer concentration and method of preparation on the solubility and dissolu...

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Hlavní autoři: Rodde, Madhuri S., Divase, Ganesh T., Devkar, Tejas B., Tekade, Avinash R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065680/
https://ncbi.nlm.nih.gov/pubmed/24995297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/463895
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