Histone/protein deacetylase SIRT1 is an anticancer therapeutic target

SIRT1, a member of the NAD(+)-dependent histone/protein deacetylase family, is involved in chromatin remodeling, DNA repair, and stress response and is a potential drug target. 5-fluorouracil (FU) and the S(N)1-type DNA methylating agent temozolomide (TMZ) are anticancer agents. In this study, we de...

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Hlavní autoři: Hwang, Bor-Jang, Madabushi, Amrita, Jin, Jin, Lin, Shiou-Yuh S, Lu, A-Lien
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2014
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065402/
https://ncbi.nlm.nih.gov/pubmed/24959376
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