Antagonistic antibody prevents toll-like receptor 2–driven lethal shock-like syndromes

Hyperactivation of immune cells by bacterial products through toll-like receptors (TLRs) is thought of as a causative mechanism of septic shock pathology. Infections with Gram-negative or Gram-positive bacteria provide TLR2-specific agonists and are the major cause of severe sepsis. In order to inte...

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Main Authors: Meng, Guangxun, Rutz, Mark, Schiemann, Matthias, Metzger, Jochen, Grabiec, Alina, Schwandner, Ralf, Luppa, Peter B., Ebel, Frank, Busch, Dirk H., Bauer, Stefan, Wagner, Hermann, Kirschning, Carsten J.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2004
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC406529/
https://ncbi.nlm.nih.gov/pubmed/15146245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420762
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