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L-selectin-mediated leukocyte tethering in shear flow is controlled by multiple contacts and cytoskeletal anchorage facilitating fast rebinding events

L-selectin-mediated tethers result in leukocyte rolling only above a threshold in shear. Here we present biophysical modeling based on recently published data from flow chamber experiments, which supports the interpretation that L-selectin-mediated tethers below the shear threshold correspond to sin...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Principais autores: Schwarz, Ulrich S., Alon, Ronen
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2004
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Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC406518/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15100404/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0305822101
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