Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors

BRAF inhibitors improve melanoma patient survival, but resistance invariably develops. Here we report the discovery of a novel BRAF mutation that confers resistance to PLX4032 employing whole-exome sequencing of drug-resistant BRAF(V600K) melanoma cells. We further describe a new screening approach,...

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Bibliographische Detailangaben
Hauptverfasser: Choi, Jaehyuk, Landrette, Sean F, Wang, Tiffany, Evans, Perry, Bacchiocchi, Antonella, Bjornson, Robert, Cheng, Elaine, Stiegler, Amy L, Gathiaka, Symon, Acevedo, Orlando, Boggon, Titus J, Krauthammer, Michael, Halaban, Ruth, Xu, Tian
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2014
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065135/
https://ncbi.nlm.nih.gov/pubmed/24283590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12197
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