Inherited Polymorphisms in Hyaluronan Synthase 1 Predict Risk of Systemic B-Cell Malignancies but Not of Breast Cancer

Genetic variations in the hyaluronan synthase 1 gene (HAS1) influence HAS1 aberrant splicing. HAS1 is aberrantly spliced in malignant cells from multiple myeloma (MM) and Waldenstrom macroglobulinemia (WM), but not in their counterparts from healthy donors. The presence of aberrant HAS1 splice varia...

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Detalhes bibliográficos
Main Authors: Kuppusamy, Hemalatha, Ogmundsdottir, Helga M., Baigorri, Eva, Warkentin, Amanda, Steingrimsdottir, Hlif, Haraldsdottir, Vilhelmina, Mant, Michael J., Mackey, John, Johnston, James B., Adamia, Sophia, Belch, Andrew R., Pilarski, Linda M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065063/
https://ncbi.nlm.nih.gov/pubmed/24950197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100691
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