Aberrant Splice Variants of HAS1 (Hyaluronan Synthase 1) Multimerize with and Modulate Normally Spliced HAS1 Protein: A POTENTIAL MECHANISM PROMOTING HUMAN CANCER

Most human genes undergo alternative splicing, but aberrant splice forms are hallmarks of many cancers, usually resulting from mutations initiating abnormal exon skipping, intron retention, or the introduction of a new splice sites. We have identified a family of aberrant splice variants of HAS1 (th...

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Hauptverfasser: Ghosh, Anirban, Kuppusamy, Hemalatha, Pilarski, Linda M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Molecular Basis of Cell and Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707203/
https://ncbi.nlm.nih.gov/pubmed/19451652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.013813
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